Renin as a key enzyme for the integrity of various critical lifefunctions in the humans

  • Dr. Skiander Ali GC University Lahore, Pakistan
  • Zainab Arshad Malik GC University Lahore, Pakistan.
  • Zahra Naeem GC University Lahore, Pakistan.
  • Ayesha Rafiq GC University Lahore, Pakistan.
DOI: https://doi.org/10.53555/as.v3i5.1286
Keywords: Renin Angiotensin system,, Juxtaglomerular cells, RAAS, ANgiotensin II,, Aliskiren, Calcium,, Kidney

Abstract

Renin Angiotensin System is the complex and old hormone system mainly involved in the
regulation of blood pressure. Renin is released by kidney & acts on Angiotensinogen to produce
Antiotensin 1 which is converted to Angiotensin II. This Angiotensin II binds to the cells through
specific receptors i.e. AT1 and AT2 to perform its functions. Renin-angiotensin-aldosterone
system maintains the amount of hormone angiotensin in body. Juxtaglomerular cells alongwith
cAMP are involved in the release and storage of rennin. Function of JG-cells is opposite to
release of calcium. A number of events regulating rennin include substances released to inhibit
calcium, presence of adenylyl cyclase, phosphodiesterases & receptors for renin and gap junction
along with calcium waves. In pathogenic conditions activity of RAAS components can cause
diseases of kidney & heart. RAAS is helpful when Angiotensin ll liberates aldosterone and water
& Na level in kidneys. Aliskiren, a rennin inhibitor can cause decrease in systolic blood pressure
and plasma rennin. In the onset of diabetes, the activation of AngII pathway supports cell growth
& its proliferation, apoptosis, oxidative stress generation etc and these all contributes in cardiac
remodeling & accelerating atherosclerosis.

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Author Biographies

Dr. Skiander Ali, GC University Lahore, Pakistan

Professor at Institute of Industrial Biotechnology,

Zainab Arshad Malik, GC University Lahore, Pakistan.

Student at Institute of Industrial Biotechnology,

Zahra Naeem, GC University Lahore, Pakistan.

Student at Institute of Industrial Biotechnology,

Ayesha Rafiq, GC University Lahore, Pakistan.

Student at Institute of Industrial Biotechnology,

Published
2017-05-31
How to Cite
Skiander Ali, D., Malik, Z. A., Naeem, Z., & Rafiq, A. (2017). Renin as a key enzyme for the integrity of various critical lifefunctions in the humans. IJRDO-Journal of Applied Science, 3(5), 38-65. https://doi.org/10.53555/as.v3i5.1286
Issue
Vol. 3 No. 5 (2017): IJRDO - Journal of Applied Science
Section
Articles

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