POTENTIAL OF MEDIUM TO LONG-TERM FASTING TO TRIGGER AN AUTOIMMUNE RESPONSE THROUGH HYPERAGGRESSIVE AUTOPHAGY
Keywords:
Caloric deficit, macroautophagy, aggrephagy, autosis, ribophagy, peroxiphagy, mitophagy, lipolysis
Abstract
Intermittent fasting is a lifestyle intervention that is increasingly gaining traction among the general population. An enhancement in the rate of autophagy is one of the fundamental results of intermittent fasting. Autophagy is a principal intracellular strategy for the maintenance of cellular, somatic, and systemic homeostasis. Gene-based and pharmacological therapeutic modalities which serve to dysregulate autophagy stimulate or exacerbate various diseases in a multiplicity of studies. Consistently, mutations in autophagy-related genetic processes may cause severe human pathologies. We review research and experimental models in order to establish a linkage between autophagy dysfunction to the pathogenesis of some major human disorders, particularly autoimmune disease.
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References
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2023-11-28
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Saxena, R. R., & Saxena, R. (2023). POTENTIAL OF MEDIUM TO LONG-TERM FASTING TO TRIGGER AN AUTOIMMUNE RESPONSE THROUGH HYPERAGGRESSIVE AUTOPHAGY. IJRDO - JOURNAL OF BIOLOGICAL SCIENCE, 9(1), 1-11. https://doi.org/10.53555/bs.v1i1.5937
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