EFFICACY OF BIOAPIGYN OINTMENT FOR PELVIC MUSCLE TONUS IN THE TREATMENT OF STRESS URINARY INCONTINENCE AND VULVOVAGNAL DISORDERS
Abstract
Objectives: The purpose of this work was development, formulation and testing of new herbal
ointment for the treatment of stress urinary incontinence and its related symptoms and
comparison of its efficiency with the results of pelvic muscle training. The influence of the
treatment or training onto vulvo-vaginal disorders was also determined.
Materials and methods: 132 women in the age range from 32 to 77 years were randomly
selected into experimental and control group. The experimental group was treated two weeks
with Bioapigyn ointment for pelvic muscle tonus (2 g/day) which consisted of the following
ingredients: honey; glycerol, Cera flava, oil macerates of the plants Capsella bursa-pastoris,
Urtica diodica, Quercus robur, Salvia officinalis, Achillea millefolium, Alchemilla vulgaris,
Calendula officinalis, Matricaria chamomilla, Plantago major; essential oils of the plants
Melaleuca alternifolia, Thymus vulgaris ct. tymol, Origanum vulgare. Control group was
subjected to pelvic muscle training during 24 weeks (three times a week). The degree of
incontinence and its impact on the quality of life prior and after the treatment or training was
assessed by the International Consultation on Incontinence Questionnaire - Urinary Incontinence
Short Form (ICIQ-UI SF), where maximum score of 21 represents permanent incontinence and 0
no leakage of urine. The volume of residual urine, perineometry and vaginal pH were also
determined before and after the treatment or training. For statistical evaluation STATISTICA
11.0 package was used.
Results: The variables with the highest, statistically significant influence onto degree of
incontinence and its impact on the quality of life were body mass index and menopause.
Significant decrease following the treatment with Bioapigyn ointment was found for ICIQ-UI SF
score (from 12.43±4.83 to 8.61±4.92, p<0.00001), residual urine volume (from 8.73±11.18 to
2.78±5.93 mL, p=0.0002) and vaginal pH (from 6.30±0.63 to 5.59±0.50, p= 0.0000). The increase
in the muscle strength was also confirmed. In the end of the treatment all the symptoms of
vulvo-vaginal disorders disappeared completely in all 66 participants. Control group also
showed some improvement in the values of ICIQ-UI SF score, residual urine and perineometry
results. However, those changes were not statistically significant. There was no improvement
concerning the vaginal pH and the symptoms of vulvo-vaginal disorders.
Conclusion: Preliminary study confirmed the efficiency of Bioapigyn ointment for pelvic muscle
tonus in the treatment of stress urinary incontinence as well as the symptoms of vulvo-vaginal
disorders due to its components with smooth muscle contraction activity, uterotonic activity as
well as pH adjusting, coating, moisturizing and soothing effect. Significantly better results for
most of the variables were found in the experimental compared to the control group.
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References
Ahmad, W., Zeenat, F., Hasan, A., Abdullah, A., Nargis, A., Tarannum, T. (2011). Mazu (Quercus infectoria, Oliv) - An Overview. Indian Journal of Unani Medicine, 4(1), 17-22.
Al-Snafi, A.E. (2015). The chemical constituents and pharmacological effects of Capsella bursa-pastoris-A review. International Journal of Pharmacology and toxicology, 5(2), 76-81.
Boskey, E.R., Telsch, K.M., Whaley, K.J., Moench, T.R., Cone, R.A. (1999). Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infection and Immunity, 67, 5170–5175.
Broncano, F.J., Rebuelta, M., Lazaro-Carrasco, M.J., Vivas, J.M. (1987). Estudio de efacto sobre musculature lisa uterine de distintos preparados de la hojas de Urtica diodica L. Anales de la Real Academia Nacional de Farmacia, 53, 69-76.
Brown, J.S., Grady, D., Ouslander, J.G., Herzog, A.R., Varner, R.E., Posner, S.F. (1999). Prevalence of Urinary Incontinence and Associated Risk Factors in Postmenopausal Women. Obstetrics & Gynecology, 94(1), 66–70.
Caillouette, J.C., Sharp, C.F. Jr, Zimmerman, G.J., Roy, S. (1997). Vaginal pH as a marker for bacterial pathogens and menopausal status. American Journal of Obstetrics and Gynecology, 176,1270–1275.
Calleja-Agius, J., Brincat, M.P. (2015.) The urogenital system and the menopause. Climacteric,18 Suppl 1,18-22
Danforth, K.N., Townsend, M.K., Lifford, K., Curhan, G.C., Resnick, N.M., Grodstein, F. (2006). Risk factors for urinary incontinence among middle-aged women. American Journal of Obstetrics and Gynecology, 194, 339–345.
EMA/HMPC/3206/2009 (2010). Assessment report on Quercus robur L., Quercus petraea Matt.) Liebl., Quercus pubescens Willd., cortex. European Medicines Agency, Committee on Herbal Medicinal Products (HMPC), p. 22
Grosso, C., Vinholes, J., Silva, L.R., Guedes de PinhoI, P., Gonçalves, R.F., Valentão P., JägerII A.K., Andrade P.B. (2011). Revista Brasileira de Farmacognosia, 21(4), http://dx.doi.org/10.1590/S0102-695X2011005000107
Gruber, C.W., O’Brien M. (2011). Uterotonic Plants and their Bioactive Constituents. Planta Medica, 77(3), 207–220.
Luber, K. M. (2004). The Definition, Prevalence, and Risk Factors for Stress Urinary Incontinence. Reviews in urology, 6(3), 3-9.
McPhil, J. H. (2004). The prevalence of stress urinary incontinence in women. Nursing time, 100(20), p.70.
Milsom, I., Arvidsson, L., Ekelund, P., Molander, U., Eriksson, O. (1993). Factors influencing vaginal cytology, pH and bacterial flora in elderly women. Acta Obstetricia et Gynecologica Scandinavica, 72, 286–291.
Minassian, V.A., Stewart, W.F., Wood, G.C. (2008). Urinary Incontinence in Women: Variation in Prevalence Estimates and Risk Factors. Obstetrics & Gynecology, 111(2), 324-331.
Nygaard, IE., Heit, M. (2004). Stress Urinary Incontinence. Obstetrics & Gynecology, 104(3), 607-620.
Oliveira, I., Sousa, A., Valenta˜o, P., Andrade, P.B., Ferreira, I.C.F.R., Ferreres, F., Bento, A., Seabra, R., Estevinho, L., Pereira, H.A. (2007). Hazel (Corylus avellana L.) leaves as source of antimicrobial and antioxidative compounds. Food Chemistry, 105, 1018–1025.
Oreščanin, V., Findri Guštek, Š., Krivak Bolanča, I. (2015a). Development and Application of New Herbal Pessaries for the Treatment of Squamous Endocervical Metaplasia. Indian Journal of Applied Research, 5(6), 176-182.
Oreščanin, V., Findri Guštek, Š. (2016). Development and Testing of New Herbal Ointment for the Treatment of Stress Urinary Incontinence-A Preliminary Study. Global Journal For Research Analysis, 5(7), 371-374.
Oreščanin, V., Findri Guštek, Š., Hunjak, B. (2015b). Application of new Herbal Pessaries for the Treatment of the Lower Genital Tract Infections. Indian Journal of Applied Research, 5(6), 510-516.
Oreščanin, V., Findri Guštek, Š. (2015c). Herbal tablets and ointment for the treatment of cervical lesions and infection of the lower female genital tract. PK20150876.
Panda, S., Das, A., Santa Singh, A., Pala, S. (2014). Vaginal pH: A marker for menopause. Journal of Midlife Health, 5(1), 34–37.
Pandit, L., Ouslander, J.G. (1997.) Postmenopausal vaginal atrophy and atrophic vaginitis. American Journal of Medical Science, 314, 228–231.
Peyrat, L., Haillot, O., Bruyere, F., Boutin, J.M., Bertrand, P., Lanson, Y. (2002). Prevalence and risk factors of urinary incontinence in young and middle-aged women. BJU International, 89(1), 61–66.
Roy, S., Caillouette, J.C., Roy, T., Faden, J.S. (2004). Vaginal pH is similar to folliclestimulating hormone for menopause diagnosis. American Journal of Obstetrics and Gynecology, 190, 1272–1277.
Shipochliev, T. (1981). Uterotonic action of extracts from a group of medicinal plants. Veterinary Med Nauki, 18(4), 94-98.
Tuntiviriyapun, P., Panyakhamlerd, K., Triratanachat, S., Chatsuwan, T., Chaikittisilpa, S., Jaisamrarn, U., Taechakraichana, N. (2015). Newly developed vaginal atrophy symptoms II and vaginal pH: a better correlation in vaginal atrophy? Climacteric, 18(2), 246-251
Vahidroodsari, F., Ayati, S., Yousefi, Z., Saeed, S. (2010). Comparing Serum FollicleStimulating Hormone (FSH) Level with Vaginal PH in Women with Menopausal Symptoms. Oman Medical Journal, 25(1), 13-26.
Zhu, L., Lang, J., Liu, C., Han, S., Huang, J., Li, X. (2009). The epidemiological study of women with urinary incontinence and risk factors for stress urinary incontinence in China. Menopause, 16(4), 831-836.
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