Antibiotic Resistance Profile of Bacteria Isolated from Clinical Lung Samples in Niamey

  • Sani OUSMANE centre de recherche médicale et Sanitaire
  • Oubayyou-Yaroukoy M. B. Centre de Recherche Médicale et Sanitaire (CERMES), Niamey, Niger
  • Moumouni H. Faculté des Sciences de la Santé, Université Abdou Moumouni de Niamey, Niamey, Niger
  • Zongo C. Centre de Recherche en Sciences Biologiques Alimentaires et Nutritionnelles, Université de Ouagadougou, Ouagadougou, Burkina Faso
  • Zida A. Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso
  • Gagara Issoufou M. A. Service de Pneumo-phtisiologie, Hôpital National Lamordé de Niamey, Niamey, Niger
  • Haoua S. Centre de Recherche Médicale et Sanitaire (CERMES), Niamey, Niger
DOI: https://doi.org/10.53555/hsn.v12i1.6561
Keywords: Antibiotic resistance, Bacteria, Lung disease, Niamey, Niger

Abstract

Background:  Since their discovery, the efficacy of antibiotics has been compromised by bacterial resistance, leading to increased morbidity, mortality, and healthcare costs globally. This issue is particularly critical in regions with limited surveillance data, such as sub-Saharan Africa.  Objectives:  This study aimed to determine the antibiotic resistance profile of bacterial strains isolated from clinical lung samples in Niamey, Niger, to inform local treatment guidelines.  Methods:  A prospective study was conducted from October 2013 to September 2016 in major hospitals in Niamey. Bacterial strains were isolated from 247 pulmonary samples. A total of 91 identified strains were tested for susceptibility to 23 antibiotics using the agar diffusion method, with interpretation based on the recommendations of the Antibiogram Committee of the French Microbiology Society (CASFM).  Results:  Of the 91 isolates, 53.86% were Gram-negative rods and 46.14% were Gram-positive cocci. Overall, 56.45% of tested isolates exhibited resistance. High resistance rates were observed, notably in Staphylococcus aureus against teicoplanin (90.47%), Stenotrophomonas maltophilia against colistin (69.24%), and Pseudomonas aeruginosa against cotrimoxazole (83.33%). Streptococcus pneumoniae showed 62.5–100% resistance to β-lactams. Enterobacteriaceae displayed resistance rates of 71.43% to 92.86% against several antibiotics, including amoxicillin, ticarcillin, and tetracycline.  Conclusion:  Bacteria responsible for lung infections in Niamey demonstrate alarming levels of resistance to commonly prescribed antibiotics. This poses a significant challenge to effective empirical treatment. The findings underscore an urgent need for implementing molecular assays to identify resistance genes, which would improve diagnostic accuracy and guide more effective therapeutic strategies.

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Published
2026-02-14
How to Cite
OUSMANE, S., Oubayyou-Yaroukoy M. B., Moumouni H., Zongo C., Zida A., Gagara Issoufou M. A., & Haoua S. (2026). Antibiotic Resistance Profile of Bacteria Isolated from Clinical Lung Samples in Niamey. IJRDO -JOURNAL OF HEALTH SCIENCES AND NURSING, 12(1), 21-26. https://doi.org/10.53555/hsn.v12i1.6561
Issue
Vol. 12 No. 1 (2026): IJRDO - Journal Of Health Sciences And Nursing (ISSN: 2456-298X)
Section
Articles

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